Conceptually, phenome-wide association studies (PheWAS) are the inverse of Genome-Wide Association Studies (GWAS). Whereas a GWAS investigates which of a million or more SNPs are associated with a single phenotype, a PheWAS investigates the association between genetic variation in a single gene with a wide range of phenotypes.
PheWAS enables the non-hypothesis driven investigation of the phenotypic consequences of normal variability of gene function in the human population. While similar in principle to investigations in knock-out animals (where a single gene is manipulated and multiple phenotypes examined), it probes the effects of smaller changes in gene function and has the obvious advantage of examining the human population directly.
PheWAS are typically used to investigate one of the following questions:
For more information on PheWAS, the implementation of PheWAS at Total Scientific or to discuss how PheWAS can help you, please contact us.
Babraham Research Campus,
Cambridge CB22 3AT
Tel: +44 (0)1223 839557
Email: info@totalscientific.com
RT @RxCelerate : Delighted to announce the acquisition of Cambridge, UK, based specialist bioanalytical #CRO @TotalScientific https://t.co/F…
All at Total Scientific would like to thank our current and past clients. We look forward to our new journey integrated with @RxCelerate .
As you may have heard TSL have been acquired by @RxCelerate , who provide bespoke drug development services to clien… https://t.co/2HIWVdGs5x
We will be @babrahamUK "Doughnut 🍩 Morning" this Thurs from 10.30 am in the Cambridge Building. Why not come and ch… https://t.co/QPI2o42Rec
Thats a nice way to end the week. Quotation accepted ! We have signed up to perform our first GLP LC-MS/MS study.… https://t.co/oh3KcuQeuv