Products & Services
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Biomarker discovery
At Total Scientific we have extensive experience in biomarker discovery, using either ‘omics technologies or traditional uniplex and multiplex immunological assays. No one can ever guarantee that a reliable biomarker for any given application can be found, but working with the experts maximises your chance of success. It is particularly important to involve us early in the process. By the time you have collected your samples for biomarker analysis it may be too late to optimise your protocol to reduce bias from other sources and maximise your potential to identify that new biomarker. Call us now for a no-obligation discussion of your needs.
Clinical studies
Navigating the maze of regulations and requirements in planning a new clinical study can be daunting. All of our clinical project managers are trained in the implementation of GCP and in complying with the EU Clinical Trials Directive (2001/20/EC), which means that we make sure that the study you require is turned from the initial stages of planning into reality with the minimum of inconvenience on your part.
In addition, throughout this process your dedicated project manager is critically appraising the protocol to ensure that your investigation into that biomarker of interest is robust and as efficient as possible.
We are happy to help you with any or all of the work required for a clinical biomarker investigation. Whether you would like help just with the design of the study, or some or all of the execution phase, trust us to deliver.
Total Scientific also has access to a wide range of existing sample collections. It may be that your biomarker discovery needs can be met from existing resources, saving time and cost. Contact us now to discuss the possibilities.
Assay development
The development of novel high throughput assays for newly discovered biomarkers is often seen as easier than the discovery stage. However, there is a big difference between the development of a new assay and a good new assay. At Total Scientific, we have extensive experience in assay development, including multiplex assays, and are able to bring all of this experience to bear on any problem you may have.
Bioanalysis
Whether it’s a newly discovered biomarker, or a traditional molecular surrogate well established for use in clinical trials, we can measure it reliably and accurately for you. Samples collected during clinical trials are often in short supply, costly to replace and therefore very precious. You can rely on Total Scientific to value your samples as highly as you do yourself, and to report the highest quality data from your study on schedule and on budget.
Choosing the right assay for your bioanalysis needs is best done before your clinical protocol is finalized. Many assays need samples collected in particular ways, or specify storage instructions. It’s also better to design the optimum aliquot sizes into the collection protocol, rather than thaw samples afterwards. Sample labeling is an unglamorous but critical part of any protocol. If you are planning a clinical study with a bioanalysis component, contact us now to discuss all the different ways we can help ensure your study is a success. The number of times we have helped clients sort out problems after the study has been run tells us how valuable our assistance in study planning really can be.
Data management and biostatistics
One of the less glamorous parts of biomarker discovery and clinical studies is the data management. However, that does not make it any less important. Just how are you going to manage all of that clinical data that is being collated from different sources? How are you going to store it? Validate it? Use it? At Total Scientific we have nearly ten years experience in the production of custom FileMaker databases for use in clinical trials and other similar laboratory applications.
In addition to data management services, we can provide custom bio-analytical or statistical services, including conventional statistical analysis or multivariate chemometric analysis of datasets with dozens or even hundreds of variables. Contact us for a no-obligation discussion of how we can unlock the real value hidden away inside your clinical datasets.
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